Uric Acid and Neuroprotection
نویسندگان
چکیده
منابع مشابه
Uric acid and neuroprotection.
Uric Acid and Neuroprotection To the Editor: Having arguably originated both sides and after longequivocation over whether urate is physiologically primarily proor antioxidant, we finally declared in favor of a neuroprotective role in acute ischemic stroke.1 But, as Dawson et al2 note, this leaves unanswered the role of xanthine oxidase and the putative pro-oxidant role of urate in atherosclero...
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Peroxynitrite, a biological oxidant formed from the reaction of nitric oxide with the superoxide radical, is associated with many pathologies, including neurodegenerative diseases, such as multiple sclerosis (MS). Gout (hyperuricemic) and MS are almost mutually exclusive, and uric acid has therapeutic effects in mice with experimental allergic encephalomyelitis, an animal disease that models MS...
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Uric acid (UA) is the end product of purine catabolism in humans and is a powerful antioxidant whose generation is increased under ischemic conditions. However, both clinical and experimental studies reveal a gradual exhaustion of the antioxidant capacity after transient cerebral ischemia, and the magnitude of this consumption seems to be correlated with the extent of brain tissue injury, growt...
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Surgical operation has long been considered capable of precipitating acute gouty arthritis (Hench, 1935; Linton and Talbott, 1943) but details of uric acid metabolism in this situation are unknown. This paper describes a study of postoperative uric acid levels in plasma and urine in a number of patients undergoing surgical operation.
متن کاملUric acid transport and disease.
Uric acid is the metabolic end product of purine metabolism in humans. It has antioxidant properties that may be protective but can also be pro-oxidant, depending on its chemical microenvironment. Hyperuricemia predisposes to disease through the formation of urate crystals that cause gout, but hyperuricemia, independent of crystal formation, has also been linked with hypertension, atheroscleros...
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ژورنال
عنوان ژورنال: Stroke
سال: 2008
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.108.524462